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Immunomodulating Phytochemicals: An Insight Into Their Potential Use in Cytokine Storm Situations
Abdusalam Abdullah Alarabei1, Nur Aimi Liyana Abd Aziz1, Nur Izah Ab Razak1
1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Advanced Pharmaceutical Bulletin
|April 8, 2024
Summary
Phytochemicals show promise in managing cytokine storm by regulating immune responses and targeting key inflammatory pathways. Further research into these plant compounds could lead to novel treatments for this life-threatening condition.
Area of Science:
- Plant-derived compounds
- Immunology
- Molecular biology
Background:
- Cytokine storm is a dangerous immune overreaction.
- Phytochemicals possess antioxidant and immunomodulatory properties.
- Phytochemicals can target immune signaling pathways.
Purpose of the Study:
- To explore phytochemicals as potential treatments for cytokine storm.
- To investigate the immunomodulatory effects of phytochemicals.
- To identify specific signaling pathways targeted by phytochemicals.
Main Methods:
- Literature review of in vivo and in vitro studies.
- Analysis of phytochemical effects on immune cell interactions.
- Identification of targeted signaling pathways (e.g., TNF-α/NF-κB, JAK/STAT).
Main Results:
- Phytochemicals modulate immune function and regulate cellular interactions.
- Phytochemicals target multiple critical cytokine storm pathways.
- Studies confirm immunomodulatory effects of various plant compounds.
Conclusions:
- Phytochemicals offer a promising complementary approach for cytokine storm management.
- Targeting specific signaling pathways with phytochemicals can control inflammation.
- Further exploration of phytochemicals is warranted for developing new therapies.
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