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Updated: Jun 29, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Subclinical atherosclerosis in multiple sclerosis.

Ruth Ann Marrie^1,2, Ronak Patel³, Stephen Allan Schaffer¹

¹Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Multiple Sclerosis Journal - Experimental, Translational and Clinical

|April 8, 2024

Summary

This summary is machine-generated.

Multiple sclerosis (MS) patients do not show increased subclinical atherosclerosis compared to those without MS. The Framingham Score effectively predicted atherosclerosis risk in both groups, indicating MS itself is not a direct risk factor for this arterial disease.

Keywords:

Multiple sclerosis epidemiology

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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Area of Science:

Cardiovascular Health
Neurology
Immunology

Background:

Multiple sclerosis (MS) is linked to a higher risk of ischemic heart disease.
Traditional vascular risk factors do not fully explain this increased cardiovascular risk in MS patients.

Purpose of the Study:

To investigate subclinical atherosclerosis in individuals with MS lacking traditional vascular risk factors.
To determine if the Framingham Score (FRS) predicts carotid intima-media thickness (CIMT) similarly in people with and without MS.

Main Methods:

Recruited participants with and without MS, excluding those with existing vascular disease.
Assessed subclinical atherosclerosis using carotid intima-media thickness (CIMT) ultrasound and defined it as CIMT ≥75th percentile.
Utilized logistic regression to analyze the association between MS, FRS, and atherosclerosis.

Main Results:

No significant difference in average CIMT or the prevalence of subclinical atherosclerosis was found between MS and non-MS cohorts.
A 1-point increase in FRS was associated with an 11% increased odds of atherosclerosis.
Multiple sclerosis status was not independently associated with subclinical atherosclerosis.

Conclusions:

Subclinical atherosclerosis is not more prevalent in individuals with MS compared to those without MS.
The Framingham Score remains a relevant predictor of atherosclerosis, independent of MS status.