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Double minute chromosomes in acute myeloblastic leukemia
Journal of the National Cancer Institute
|May 1, 1985
Summary
Double minute chromosomes (dmins) in acute myeloblastic leukemia (AML) were observed in two patients. Dmin presence and disappearance correlated with remission, suggesting their role in AML progression and treatment response.
Area of Science:
- Hematology
- Oncology
- Cytogenetics
Background:
- Double minute chromosomes (dmins) are extrachromosomal elements often associated with oncogene amplification.
- Their role in acute myeloblastic leukemia (AML) is not fully understood.
- This study examines two AML cases with dmins.