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Updated: May 6, 2026
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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
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Brain Structural and Functional Abnormalities Associated with Acute Post-Traumatic Headache: Iron Deposition and
Simona Nikolova1, Catherine Chong1, Jing Li2
1Mayo Clinic.
Research Square
|April 8, 2024
Summary
Brain iron accumulation, indicated by lower T2* values, was found in individuals with acute post-traumatic headache (PTH) following mild traumatic brain injury (mTBI). This iron buildup correlates with increased headache frequency and symptom severity.
Area of Science:
- Neuroimaging
- Neurology
- Traumatic Brain Injury Research
Background:
- Mild traumatic brain injury (mTBI) can lead to acute post-traumatic headache (PTH).
- Brain iron accumulation is a potential consequence of mTBI.
- The relationship between iron accumulation, functional connectivity, and PTH symptoms requires further investigation.
Conclusions:
- Iron accumulation in the posterior cingulate and cuneus is present in acute PTH post-mTBI.
- Altered functional connectivity between the cuneus and cerebellum was noted in PTH patients.
- Iron accumulation may reflect mTBI pathophysiology severity and associate with PTH symptoms.
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