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Updated: Jun 29, 2025
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
Identification of non-canonical peptides with moPepGen
Chenghao Zhu1,2,3,4, Lydia Y Liu1,2,5,6,7, Annie Ha5,6
1Department of Human Genetics, University of California, Los Angeles, CA, USA.
Abstract:
Proteogenomics is limited by challenges of modeling the complexities of gene expression. We create moPepGen, a graph-based algorithm that comprehensively generates non-canonical peptides in linear time. moPepGen works with multiple technologies, in multiple species and on all types of genetic and transcriptomic data. In human cancer proteomes, it enumerates previously unobservable noncanonical peptides arising from germline and somatic genomic variants, noncoding open reading frames, RNA fusions and RNA circularization.
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