Assessing Post-TAVR Cardiac Conduction Abnormalities Risk Using a Digital Twin of a Beating Heart

Area of Science:

• Cardiovascular Medicine
• Biomedical Engineering
• Computational Biology

Background:

• Transcatheter aortic valve replacement (TAVR) is increasingly preferred over surgical aortic valve replacement (SAVR).
• Cardiac conduction abnormalities (CCA) remain a significant complication following TAVR.
• Pressure from the TAVR stent on cardiac conduction fibers near the AV node can cause CCA.

Conclusions:

• Implantation depth and pre-existing conduction abnormalities critically influence post-TAVR CCA risk.
• Aortic deployment and LBBB may mitigate CCA risk, whereas deeper placement and RBBB elevate it.
• The in-silico model provides valuable insights for predicting and potentially preventing TAVR-related conduction issues.