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The Association Between Thyroid Hormones and Renal Function in Euthyroid Chinese Individuals: A Population-Based
Zheng-Xin Liu1, Jin-Lin Lv1, Yu-Luan Xiang1
1Department of Gerontology, The First Affiliated Hospital of Dali University, Dali, CHN.
Cureus
|April 8, 2024
Summary
Thyroid hormones impact kidney function in euthyroid Chinese adults. Lower free triiodothyronine (FT3) and total triiodothyronine (TT3) levels, along with higher thyroid-stimulating hormone (TSH), were linked to reduced glomerular filtration rate (GFR).
Area of Science:
- Endocrinology
- Nephrology
- Internal Medicine
Background:
- The relationship between thyroid hormones and renal function in euthyroid Chinese individuals is not well understood.
- Thyroid dysfunction is a known risk factor for chronic kidney disease (CKD).
Purpose of the Study:
- To investigate the association between thyroid hormone levels and renal function in euthyroid Chinese individuals.
- To explore the link between thyroid hormones and the risk of chronic kidney disease (CKD) in this population.
Main Methods:
- A cross-sectional study of 661 euthyroid Chinese individuals.
- Assessment of glomerular filtration rate (GFR) and urine albumin-to-creatinine ratio (ACR).
- Statistical analysis adjusted for covariates to determine associations between thyroid hormones (FT3, TT3, TT4, TSH) and renal function markers.
Main Results:
- Higher free triiodothyronine (FT3) and total triiodothyronine (TT3) levels were associated with increased GFR.
- Higher thyroid-stimulating hormone (TSH) levels were associated with decreased GFR.
- Higher TT3 and total thyroxine (TT4) levels were associated with a reduced risk of CKD, while no association was found with ACR.
Conclusions:
- Thyroid function is significantly associated with GFR in euthyroid Chinese individuals.
- Lower FT3, TT3, and higher TSH levels may indicate reduced renal function.
- Lower TT3 and TT4 levels are linked to an increased risk of CKD, suggesting a role for thyroid hormones in maintaining renal health.
Keywords:
albumin-to-creatinine ratiochronic kidney diseaseglomerular filtration raterenal functionthyroid hormoneMore Related Videos
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