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Updated: Jul 9, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Upadacitinib-Induced Hepatitis B Reactivation Leading to Liver Transplant
Sarosh Ahmed Khan1, Rida Zahid2, Muhammad Amir3
1Department of Medicine, Integris Baptist Medical Center, Oklahoma City, OK.
Abstract:
Hepatitis B virus (HBV) reactivation can occur with the use of immunosuppressive therapy used to treat autoimmune conditions, such as rheumatoid arthritis. Janus kinase inhibitors, such as upadacitinib, have been approved for the treatment of rheumatoid arthritis. This is the first case report of a patient who used upadacitinib without antiviral prophylaxis against HBV and developed HBV reactivation, leading to fulminant hepatic failure necessitating emergent liver transplantation.
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