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Updated: Jun 29, 2025

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Alpha-synuclein pathology in isolated rapid eye movement sleep behaviour disorder: a meta-analysis

Imran H Iftikhar1,2, Sohaila AlShimemeri3, Hussein Rabah1

  • 1Department of Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Journal of Sleep Research
|April 8, 2024
PubMed
Summary

Testing for alpha-synuclein (a-Syn) in patients with isolated rapid eye movement sleep behaviour disorder (iRBD) shows high positivity. Skin biopsies are preferred over CSF, and phosphorylated a-Syn (p-syn) is more specific than seeding assays.

Keywords:
alpha‐synuclein seed amplification assayalpha‐synucleinopathycerebrospinal fluidmeta‐analysisphenoconversionrapid eye movment sleep behaviour disorder

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