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ICTV Virus Taxonomy Profile: Hantaviridae 2024
Steven B Bradfute1, Charles H Calisher2, Boris Klempa3
1University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
The Journal of General Virology
|April 8, 2024
Summary
Hantaviridae are RNA viruses transmitted by animals, with some orthohantaviruses causing severe human diseases. This summary details their viral structure and genomic components.
Area of Science:
- Virology
- Molecular Biology
- Taxonomy
Background:
- Hantaviridae are negative-sense RNA viruses with genomes of 10.5–14.6 kb.
- These viruses are transmitted by fish, reptiles, and mammals.
- Certain orthohantaviruses cause mild to fatal human diseases.
Purpose of the Study:
- To summarize the International Committee on Taxonomy of Viruses (ICTV) report on the Hantaviridae family.
- To provide an overview of Hantaviridae taxonomy and characteristics.
Main Methods:
- Review and summarization of the ICTV report on Hantaviridae.
- Analysis of viral genome structure and protein-coding regions.
Main Results:
- Hantaviridae possess enveloped virions with three single-stranded RNA segments.
- These segments encode essential viral proteins: nucleoprotein (N), glycoprotein precursor (GPC), and large (L) protein with RNA-directed RNA polymerase (RdRP) activity.
Conclusions:
- The ICTV report provides a comprehensive classification and description of the Hantaviridae family.
- Understanding Hantaviridae structure and transmission is crucial for public health and disease prevention.
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