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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

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Rutin alleviates Sjogren's syndrome via CaR/NLRP3/NF-κB signal pathway

Jing He1, Meimei Xu1, Suling Wu2

  • 1Department of Rheumatology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

In Vitro Cellular & Developmental Biology. Animal
|April 8, 2024
PubMed

Insights

Rutin (Ru) demonstrates potential in treating Sjogren

Area of Science:

  • Immunology
  • Biochemistry
  • Pharmacology

Background:

  • Sjogren's syndrome (SS) is an autoimmune disorder with unclear mechanisms and treatments.
  • The submandibular glands are affected in SS, impacting salivary function.
  • Calcium-sensing receptor (CaR) is implicated in SS pathogenesis.

Purpose of the Study:

  • To investigate the therapeutic effects of rutin (Ru) on Sjogren's syndrome (SS).
  • To explore the role of the calcium-sensing receptor (CaR)/NLRP3/NF-κB pathway in SS.
  • To identify potential therapeutic targets for SS treatment.

Main Methods:

  • Proteomics analysis to identify differential proteins in SS mouse submandibular glands.
  • Assessment of salivary secretion (SAS) and salivary gland index (SGI).
  • Detection of oxidative stress, inflammatory cytokines, and key pathway proteins (NLRP3, ASC, Caspase-1, IL-1β, p-NF-κBp65).

Main Results:

  • 327 differential proteins were identified in SS mice, with CaR significantly increased.
  • Rutin (Ru) improved SGI, inhibited oxidative stress, and reduced inflammatory cytokines.
  • Rutin's efficacy involved regulating the CaR/NLRP3/NF-κB pathway, with CaR overexpression partially counteracting Ru's effects.

Conclusions:

  • Rutin (Ru) shows therapeutic potential for Sjogren's syndrome (SS) by modulating the CaR/NLRP3/NF-κB pathway.
  • Calcium-sensing receptor (CaR) is a potential therapeutic target for SS.
  • This study provides a foundation for developing novel SS treatments.
Keywords:
Calcium-sensing receptorNF-κBNLRP3Sjogren’s syndrome

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