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Updated: Jun 29, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Associations Between Early-Life Adversity, Ambient Air Pollution, and Telomere Length in Children

Rosemarie de la Rosa1, Austin Le, Stephanie Holm

  • 1From the Environmental Health Sciences Division, School of Public Health (de la Rosa, Le), University of California, Berkeley, Berkeley, California; Division of Pulmonary and Critical Care Medicine, Department of Medicine (de la Rosa, Ye, Thakur), University of California, San Francisco; Western States Pediatric Environmental Health Specialty Unit (Holm); Departments of Psychiatry and Behavioral Science (Bush), Pediatrics (Bush, Long), and Family and Community Medicine (Hessler), University of California, San Francisco; Center for Youth Wellness (Koita, Bucci); and UCSF Benioff Children's Hospital Oakland (Long), San Francisco, California.

Psychosomatic Medicine
|April 8, 2024
PubMed
Summary

Early-life adversity, specifically adverse social context, may worsen the impact of air pollution on children's telomere length. Chronic fine particulate matter (PM 2.5) exposure accelerates telomere shortening in children facing social challenges.

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