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Related Concept Videos

The DNA Helix01:16

The DNA Helix

Overview
DNA Packaging00:58

DNA Packaging

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The DNA Helix01:16

The DNA Helix

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DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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Updated: May 9, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Chiroplasmonic DNA Scaffolded "Fusilli" Structures.

Alessandro Cecconello1, Aura Cencini1, Graziano Rilievo1

  • 1Department of Comparative Biomedicine and Food Science, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.

Nano Letters
|April 8, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a DNA assembly strategy to create long, tubular scaffolds. These scaffolds precisely position plasmonic nanoparticles in a helical "fusilli" shape, yielding novel chiroptical nanomaterials for metamaterial applications.

Keywords:
chiralitycircular dichroismgold nanoparticlehelixnanomaterialself-assembly

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomaterials Engineering

Background:

  • DNA's unique properties enable the design of advanced nanoarchitectures.
  • Self-assembly of DNA structures is crucial for creating complex nanomaterials.

Purpose of the Study:

  • To optimize DNA assembly for concatenating quasi-rings into long scaffolds.
  • To utilize these DNA scaffolds for precise nanoparticle arrangement.
  • To investigate the chiroptical properties of the resulting nanostructures.

Main Methods:

  • Optimized ionic strength (15 mM MgCl2) for DNA quasi-ring self-assembly.
  • Atomic Force Microscopy (AFM) for characterizing DNA tubular structures.
  • High-resolution Scanning Transmission Electron Microscopy (HR-STEM) for imaging nanoparticle distribution.
  • DNA tethers for positioning plasmonic nanoparticles.
  • Circular Dichroism (CD) spectroscopy for chiroptical analysis.

Main Results:

  • Successfully assembled micrometer-long DNA tubular scaffolds.
  • Positioned plasmonic nanoparticles in a 3D helical "fusilli" arrangement along the scaffolds.
  • Observed bisignated CD absorption, confirming chiroptical activity.
  • Demonstrated the potential for large-scale DNA-based nanomaterial assembly.

Conclusions:

  • Developed an effective strategy for creating long DNA scaffolds for nanomaterial fabrication.
  • Engineered DNA-nanoparticle assemblies with tunable helical structures and chiroptical properties.
  • These findings advance the field of chiroplasmonic DNA-based nanomaterials for future metamaterial applications.