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Evolutionary amplification of a pseudogene.

P Ghazal, A J Clark, J O Bishop

    Proceedings of the National Academy of Sciences of the United States of America
    |June 1, 1985
    PubMed
    Summary
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    Mouse major urinary protein (MUP) gene families show close relationships within groups but divergence between them. Amplification of these gene pairs likely occurred after a mutation event in their common ancestor.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Genomics

    Background:

    • The mouse major urinary protein (MUP) gene family comprises approximately 35 members located on chromosome 4.
    • These genes are organized into two main subfamilies, group 1 and group 2, with 12-15 members each.
    • Previous research indicated that most group 1 and group 2 genes form pairs, transcribed divergently with 15 kb between cap sites.

    Purpose of the Study:

    • To present the nucleotide sequence of the first exon for six group 1 and four group 2 MUP genes.
    • To confirm the evolutionary relationships within and between MUP gene subfamilies.
    • To investigate the potential unit of MUP gene amplification.

    Main Methods:

    • Nucleotide sequencing of the first exon of selected group 1 and group 2 MUP genes.

    Related Experiment Videos

  • Comparative sequence analysis to assess gene relationships.
  • Analysis of gene arrangement and flanking regions.

    • Main Results:

    • Sequencing data confirmed close genetic relationships within each MUP subfamily (group 1 and group 2).
    • Significant divergence was observed between the group 1 and group 2 subfamilies.
    • All four sequenced group 2 genes shared a nonsense mutation in codon 7, suggesting a common ancestral pseudogene.
    • The size of each MUP gene pair, including flanking regions, is approximately 45 kilobases.

    Conclusions:

    • The findings support the hypothesis that MUP gene amplification occurs in 45 kb domains.
    • The data suggest that MUP gene amplification followed an ancestral mutation event, leading to pseudogenization.
    • The study elucidates the structural organization and evolutionary history of the mouse MUP gene family.