Extramammary Paget disease. Part II. Evidence-based approach to management.

Area of Science:

• Dermatology
• Oncology
• Surgical Oncology

Background:

• Extramammary Paget disease (EMPD) is a rare, aggressive skin cancer.
• EMPD commonly affects elderly individuals in the genital, perianal, and axillary regions.
• Delayed diagnosis and treatment of EMPD contribute to significant patient morbidity.

Purpose of the Study:

• To provide a comprehensive overview of EMPD management.
• To discuss current and emerging therapeutic options for EMPD.
• To inform evidence-based clinical decision-making for EMPD patients.

Main Methods:

• This is Part 2 of a continuing medical education series.
• Review of current literature on surgical and noninvasive therapies for EMPD.
• Exploration of novel treatment approaches for advanced-stage EMPD.

Main Results:

• Surgical interventions remain a cornerstone of EMPD treatment.
• Noninvasive therapies offer alternative or adjuvant treatment options.
• Novel approaches are being investigated for refractory or advanced EMPD.

Conclusions:

• Optimal management of EMPD involves a multidisciplinary approach.
• Tailoring treatment to disease stage and patient factors is crucial.
• Continued research into novel therapies is essential for improving outcomes in advanced EMPD.