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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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Dissociative Disorders01:27

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Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
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High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

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Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
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Neurotransmitters01:31

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Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Related Experiment Video

Updated: Jun 29, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Dynamic Functional Hyperconnectivity After Psilocybin Intake Is Primarily Associated With Oceanic Boundlessness.

Sepehr Mortaheb1, Larry D Fort1, Natasha L Mason2

  • 1Physiology of Cognition, GIGA Research, CRC Human Imaging Unit, University of Liège, Liège, Belgium; Fund for Scientific Research FNRS, Brussels, Belgium.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|April 8, 2024
PubMed
Summary

Psilocybin alters brain connectivity and subjective experience, revealing a hyperconnected brain state linked to profound psychological changes. This study links brain dynamics to the psychedelic experience, offering new insights.

Keywords:
5D-ASCConnectivityDynamicsGlobal signalPsilocybinfMRI

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Consciousness Studies

Background:

  • The relationship between neurobiology and subjective experience during psychedelic states is not well understood.
  • Psilocybin is a psychedelic compound known to induce altered states of consciousness.
  • Previous research often analyzes neurobiological and experiential patterns separately.

Purpose of the Study:

  • To investigate the connection between neurobiological patterns and subjective experiences after psilocybin administration.
  • To explore the link between dynamic cerebral connectivity and retrospective questionnaire data.
  • To characterize the neuroexperiential correlates of the psychedelic state.

Main Methods:

  • Healthy participants received psilocybin or placebo and underwent 7T MRI scanning.
  • Functional connectivity was assessed during an eyes-open resting state at peak drug effect.
  • The 5-Dimensional Altered States of Consciousness Rating Scale measured subjective experiences.

Main Results:

  • Psilocybin induced widespread increases in brain functional connectivity and altered all dimensions of subjective experience.
  • Time-varying analysis revealed a recurrent hyperconnected pattern associated with heightened cortical arousal.
  • Increased transition probabilities to this hyperconnected state correlated with feelings of oceanic boundlessness and visionary restructuralization.

Conclusions:

  • Psilocybin causes significant changes in both brain function and subjective experience.
  • The hyperconnected-hyperarousal brain pattern under psilocybin may facilitate novel mental associations.
  • Findings illuminate the interplay between brain dynamics and subjective experience, offering insights into psychedelic states.