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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Breast cancer drug resistance: Decoding the roles of Hippo pathway crosstalk

Fariba Dehghanian1, Laleh Ebrahimi Ghahnavieh1, Amirhossein Naghsh Nilchi1

  • 1Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, HezarJarib Street, Isfahan 81746-73441, Iran.

Gene
|April 8, 2024
PubMed

Insights

Drug resistance in breast cancer (BC) poses a major challenge. This review highlights the Hippo pathway's role in BC drug resistance and explores potential therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Breast cancer (BC) remains a leading cause of cancer-related death, significantly influenced by drug resistance, metastasis, and invasion.
  • Chemotherapy resistance in BC is a complex clinical challenge, driven by diverse molecular mechanisms and the cancer's heterogeneous nature.
  • Recent research implicates the deregulation of signaling pathways, notably the Hippo pathway (HP), in the development of BC drug resistance.

Purpose of the Study:

  • This review summarizes the molecular mechanisms underlying Hippo pathway (HP) deregulation in breast cancer (BC) drug resistance.
  • It focuses on the Hippo pathway as a recent area of cancer research and its specific implications in BC chemoresistance.
  • The review aims to explore HP's crosstalk with other signaling pathways and evaluate the potential of HP inhibitors for overcoming resistance.

Main Methods:

  • Literature review of recent studies on breast cancer signaling pathways and drug resistance.
  • Analysis of molecular mechanisms involving the Hippo pathway (HP) in BC.
  • Examination of the crosstalk between HP and other signaling pathways relevant to chemoresistance.

Main Results:

  • Deregulation of the Hippo pathway (HP) is identified as a key molecular mechanism contributing to drug resistance in breast cancer (BC).
  • The review details the complex interplay and crosstalk between HP and other signaling pathways involved in BC progression and resistance.
  • Understanding these molecular underpinnings is crucial for developing effective therapeutic strategies.

Conclusions:

  • The Hippo pathway (HP) plays a significant role in the molecular basis of drug resistance in breast cancer (BC).
  • Further investigation into HP's function and its interactions with other pathways is essential for advancing BC treatment.
  • Targeting the Hippo pathway holds promise for developing novel therapeutic strategies to overcome chemoresistance in BC patients.
Keywords:
Breast cancerDrug resistanceHippo signaling pathwayMolecular mechanisms

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