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Updated: Jun 29, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
A simplified longitudinal model for the development of Type 2 Diabetes Mellitus
Andrea De Gaetano1, Ilona Nagy2, Daniel Kiss3
1Consiglio Nazionale delle Ricerche, CNR-IASI Rome and CNR-IRIB Palermo, Italy; Department of Biomatics, Óbuda University, Budapest, Hungary.
Abstract:
Obesity and diabetes are a progressively more and more deleterious hallmark of modern, well fed societies. In order to study the potential impact of strategies designed to obviate the pathological consequences of detrimental lifestyles, a model for the development of Type 2 diabetes geared towards large population simulations would be useful. The present work introduces such a model, representing in simplified fashion the interplay between average glycemia, average insulinemia and functional beta-cell mass, and incorporating the effects of excess food intake or, conversely, of physical activity levels. Qualitative properties of the model are formally established and simulations are shown as examples of its use.
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