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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

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Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia

Menghan Li^1,2,3, Ya Shi^1,2, Qiuying Chen^1,2

¹Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China.

BMJ Open Ophthalmology

|April 8, 2024

Summary

This summary is machine-generated.

High myopia (HM) eyes show greater macular choroidal thickness (ChT) reduction over two years. Baseline peripapillary atrophy (PPA) area and axial elongation predict this ChT decrease in myopia.

Keywords:

Choroid Clinical Trial Epidemiology Imaging Public health

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Area of Science:

Ophthalmology
Retinal Imaging
Myopia Research

Background:

Myopia is a growing public health concern.
Choroidal thickness (ChT) changes are crucial in myopia progression.
Peripapillary atrophy (PPA) and axial elongation are linked to myopic changes.

Purpose of the Study:

To investigate how peripapillary atrophy (PPA) area and axial elongation influence longitudinal changes in macular choroidal thickness (ChT) in young myopic individuals.
To assess the predictive capability of PPA area and axial elongation for macular ChT reduction.

Main Methods:

A 2-year longitudinal study involving 431 eyes (342 non-high myopia, 89 high myopia).
Swept-source optical coherence tomography was used for measurements.
Macular ChT, PPA area, and axial length (AL) were measured at baseline and follow-up.
Multiple regression and ROC curve analyses were performed.

Main Results:

High myopia (HM) eyes showed significantly greater macular ChT reduction (-7.35±11.70 µm) compared to non-high myopia (non-HM) eyes (-1.85±16.95 µm).
Increased ChT reduction was associated with larger baseline PPA area (β=-26.646) and greater axial elongation (β=-35.230).
The combination of baseline PPA area and AL change predicted macular ChT decrease with an AUC of 0.741.

Conclusions:

Eyes with high myopia experience a more significant decrease in macular choroidal thickness over two years.
Baseline peripapillary atrophy area and axial elongation are key predictors of macular choroidal thickness reduction in myopia.