Related Experiment Video
Updated: Jun 29, 2025

Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
Published on: July 28, 2018
Combination of diuretics for acute heart failure: a protocol for a systematic review of randomised clinical trials
Nihal Nahiz1, Jasmin Dam Lukoschewitz2, Ekim Seven3
1Department of Cardiology, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark wdb580@alumni.ku.dk.
Introduction:
Acute heart failure (AHF) is a critical, costly condition with high mortality rates, affecting millions annually. Despite advances in cardiovascular care, AHF treatment lacks robust evidence. AHF commonly manifests with sudden heart failure symptoms such as pulmonary congestion, and the pathophysiology involves fluid overload. Initial treatment is based on intravenous diuretics typically, but the optimal combination of drugs remains uncertain.
Methods And Analysis:
We will systematically review randomised controlled trials enrolling patients with AHF and volume overload undergoing in-hospital diuretic treatment. We aim to investigate any diuretic intervention. Our search strategy includes the following databases: Embase, Medline, Latin American and Caribbean Health Sciences Literature, Web of Science and the Cochrane Central Register of Controlled Trials. The primary outcome is all-cause mortality. Secondary outcomes are serious adverse events, hospital readmission and kidney failure. Study results reported at the most extended follow-up will be used for all outcomes. If appropriate, we will conduct meta-analysis, trial sequential analysis and network meta-analysis.
Ethics And Dissemination:
No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field.
Prospero Registration Number:
CRD42023463979.
More Related Videos
09:20Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
10:38Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
Related Concept Videos
Heart Failure Drugs: Diuretics
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Heart Failure Drugs: Inotropic Agents
Heart Failure Drugs: β-Blockers
Antihypertensive Drugs: Action of Diuretics
Antihypertensive Drugs: Potassium-Sparing Diuretics