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  11. Circsnx6 Promotes Proliferation, Metastasis, And Angiogenesis In Hepatocellular Carcinoma Via Mir-383-5p/vegfa Signaling Pathway.

CircSNX6 promotes proliferation, metastasis, and angiogenesis in hepatocellular carcinoma via miR-383-5p/VEGFA signaling pathway.

Yuan Tian1, Wenwen Han2, Kaiji Lv1

  • 1Department of General Surgery, Ningbo Medical Center Lihuili Hospital, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315100, Zhejiang, China.

Scientific Reports
|April 8, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Circular RNA SNX6 (circSNX6) promotes hepatocellular carcinoma (HCC) progression by regulating the miR-383-5p/VEGFA pathway. Silencing circSNX6 inhibits HCC cell growth, invasion, and metastasis in vitro and in vivo.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) play a regulatory role in hepatocellular carcinoma (HCC).
  • The specific mechanisms of circSNX6 in HCC progression require further elucidation.
  • Previous studies suggest circSNX6 influences HCC cells and tissues.

Purpose of the Study:

  • To investigate the role and mechanism of circSNX6 in hepatocellular carcinoma (HCC) progression.
  • To determine the relationship between circSNX6, miR-383-5p, and VEGFA in HCC.
  • To evaluate the therapeutic potential of targeting circSNX6 in HCC.

Main Methods:

  • Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for expression analysis.
  • In vitro assays (proliferation, migration, invasion, angiogenesis) and in vivo xenograft models.
Keywords:
Circular RNAsHepatocellular carcinomaVEGFAcircSNX6

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  • RNA immunoprecipitation (RIP) chip and dual-luciferase reporter assays to confirm molecular interactions.

    • Main Results:

    • circSNX6 expression is elevated in HCC tissues and correlates with poor prognosis.
    • circSNX6 knockdown suppresses HCC cell proliferation, invasion, metastasis, and angiogenesis.
    • circSNX6 targets miR-383-5p, which in turn regulates VEGFA, impacting HCC progression.

    Conclusions:

    • circSNX6 promotes HCC progression by modulating the miR-383-5p/VEGFA axis.
    • circSNX6 acts as a potential oncogene in hepatocellular carcinoma.
    • Targeting circSNX6 may offer a novel therapeutic strategy for HCC treatment.
    miR-383-5p