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Updated: Jun 29, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

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"Association between perinatal mood disorders of parents and child health outcomes"

Erika Obikane1,2, Hayato Yamana3,4, Sachiko Ono5

  • 1Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo, Japan. obikane-e@ncchd.go.jp.

Archives of Women'S Mental Health
|April 8, 2024
PubMed

Insights

Maternal perinatal mood disorders are linked to adverse child development, including developmental delays and behavioral issues. Paternal mood disorders showed no significant association with negative pediatric outcomes in this Japanese study.

Area of Science:

  • Perinatal mental health research
  • Child development studies
  • Epidemiology of parental mental illness

Background:

  • Perinatal mood disorders impact parents and children.
  • Limited understanding of parental perinatal mood disorders and pediatric outcomes in Japan.
  • Need to consider covariates like parental age and antidepressant use.

Purpose of the Study:

  • Investigate the association between paternal and maternal perinatal mood disorders and child outcomes up to 36 months.
  • Adjust for covariates: child's sex, parental age, other parent's mood disorder, and perinatal antidepressant use.
  • Examine physical and psychological child outcomes.

Main Methods:

  • Utilized the JMDC Claims Database in Japan (2012-2020).
  • Defined perinatal mood disorders using ICD-10 codes and psychiatric treatment codes.
  • Employed Cox proportional hazard models for association analysis.

Main Results:

  • Analyzed 116,423 father-mother-child triads.
  • Paternal perinatal mood disorders showed no significant association with adverse child outcomes.
  • Maternal perinatal mood disorders linked to delayed motor development, language disorders, autism spectrum disorders, and behavioral/emotional disorders.

Conclusions:

  • Paternal perinatal mood disorders were not associated with adverse child outcomes in this cohort.
  • Maternal perinatal mood disorders demonstrated significant associations with multiple adverse child outcomes.
Abstract

Keywords:
Child healthMaternal depressionMental healthPaternal depressionPerinatal depression

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