[Role of Ferroptosis in Non-small Cell Lung Cancer and Progress 
of Traditional Chinese Medicine Intervention]

Area of Science:

• Oncology
• Cell Death Mechanisms
• Pharmacology

Background:

• Non-small cell lung cancer (NSCLC) presents a significant global health challenge due to high morbidity and mortality.
• Emerging resistance to chemotherapy and radiotherapy necessitates novel therapeutic approaches for NSCLC.
• Ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, is increasingly implicated in NSCLC pathogenesis.

Approach:

• This review explores the intricate mechanisms of ferroptosis in the context of NSCLC.
• It examines the current research on traditional Chinese medicine (TCM) interventions targeting ferroptosis in NSCLC.
• The review covers active ingredients, single herbs, and compound formulations of TCM.

Key Points:

• Ferroptosis is regulated by the interplay of iron metabolism, lipid metabolism, and reactive oxygen species (ROS).
• TCM offers a multi-targeted approach with potentially fewer side effects for NSCLC management.
• TCM components demonstrate potential in modulating ferroptosis pathways for NSCLC treatment.

Conclusions:

• Understanding ferroptosis mechanisms provides a new avenue for NSCLC drug development.
• Targeting ferroptosis with TCM presents a promising strategy for overcoming treatment resistance in NSCLC.
• This review provides a theoretical foundation for utilizing TCM to target ferroptosis in NSCLC prevention and treatment.