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Predictive nomogram for bone metastases in lung cancer based on monocyte infiltration
Zhangyan Ke1,2, Meiling Zhao3, Furong Meng1,2
1Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui, China.
American Journal of Cancer Research
|April 9, 2024
Summary
This study identified key risk factors for bone metastases in lung cancer patients, including histological type, medical history, monocyte percentage, and lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels. A validated nomogram aids in predicting bone metastasis risk.
Area of Science:
- Oncology
- Cancer Metastasis Research
Background:
- Bone metastases (BM) significantly worsen prognosis in lung cancer patients.
- Identifying risk factors for BM is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate risk factors associated with bone metastases (BM) in lung cancer.
- To develop and validate a prognostic nomogram for predicting BM in lung cancer.
Main Methods:
- Retrospective analysis of 462 lung cancer patients.
- Univariate and multivariate analyses to identify independent risk factors.
- Construction and validation of a prognostic nomogram using various statistical methods.
- In vitro assays (cell co-culture, Transwell, wound-healing) and immunohistochemistry/immunofluorescence to assess monocyte influence.
Main Results:
- Histological type, medical history, monocyte percentage, and levels of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) were identified as independent risk factors for BM.
- Co-culture with monocytes enhanced lung cancer cell migration and invasion in vitro.
- Increased monocyte infiltration was observed in primary tumors of patients with BM.
Conclusions:
- A precise, straightforward, and cost-effective prognostic nomogram for lung cancer with bone metastases was successfully constructed and validated.
- Monocytes play a significant role in promoting lung cancer bone metastasis.
