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Updated: Jun 29, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Role of co‑inhibitory molecules in the treatment of psoriasis (Review)

Yue Yao1,2, Linxi Zeng1,2, Xin Huang1,2

  • 1Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China.

Experimental and Therapeutic Medicine
|April 9, 2024
PubMed

Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in the pathogenesis of psoriasis. While T-cell activation not only requires the first recognition of T-cell receptor and major histocompatibility complex peptide, co-stimulatory and co-inhibitory pathways are reported to promote or dampen T-cell responses through a variety of mechanisms. In recent years, immuno-related agents have been applied in the treatment of numerous clinical diseases, including psoriasis, and are starting to show promising and potential therapy prospects in autoimmune skin diseases. The present review outlined the role of co-inhibitory molecules in the pathogenesis of psoriasis and their application in the treatment of psoriasis.

Keywords:
T-cell immunoglobulin and mucin domain-containing protein 3co-inhibitory moleculescytotoxic T lymphocyte antigen-4lymphocyte-activation gene 3programmed death 1psoriasis

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