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Published on: July 18, 2014
Clinical presentation of severe COVID‑19 with heart failure: A single‑center retrospective study
Xinling Liu1, Tingting Liu1, Rong Wan1
1Department of Quality Management, The 904th Hospital of Joint Logistic Support Force (Wuxi Taihu Hospital), Wuxi, Jiangsu 214044, P.R. China.
Insights
Patients with severe heart failure (HF) and coronavirus disease-19 (COVID-19) experienced worse outcomes, including higher mortality and longer hospital stays. This highlights the critical need for improved care strategies during pandemics.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic significantly impacted public health interventions globally.
- Severe heart failure (HF) presents unique challenges, especially when compounded by severe infections like COVID-19.
Purpose of the Study:
- To evaluate the clinical features and outcomes of severe heart failure (HF) in patients with severe coronavirus disease-19 (COVID-19).
- To compare outcomes between severe HF patients with and without COVID-19.
Main Methods:
- A single-center observational study conducted in Wuxi, China, from November 2022 to April 2023.
- Included 210 patients diagnosed with severe HF, with 128 having concurrent COVID-19.
- Analyzed medical records including laboratory values, hospitalization length, mortality, and costs.
Main Results:
- No significant differences in baseline characteristics were found between groups.
- HF combined with COVID-19 showed significantly increased 30-day mortality (28.91% vs. 14.63%).
- Patients with HF and COVID-19 experienced longer hospital stays, higher hospitalization costs, and increased rates of complications like pneumonia, respiratory failure, and delirium.
Conclusions:
- Heart failure combined with COVID-19 leads to significantly worse treatment outcomes and prognosis.
- Understanding these impacts is crucial for refining care for HF patients during pandemics.
- Enhanced preparedness for future pandemics requires specific attention to vulnerable populations like those with severe HF.
Abstract:
The coronavirus disease-19 (COVID-19) pandemic has led to a global transformation in public health interventions. The present study aimed to evaluate the clinical features as well as the outcomes of severe heart failure (HF) among patients with severe COVID-19. A single-center observational study was carried out at The 904th Hospital of Joint Logistic Support Force (Wuxi, China) from November 2022 to April 2023, and a total of 210 patients diagnosed with severe HF were included. Among these patients, 128 patients had COVID-19 whereas the remaining patients were not diagnosed with COVID-19. The analysis entailed investigated pre-existing medical records, that is, admission and discharge, laboratory values, neuroimaging, length of hospitalization, mortality and costs incurred by patients throughout the COVID-19 pandemic from the records. All the 210 incorporated patients accomplished the follow-up and it was established that there was no significant differences in baseline characteristics between HF combined with COVID-19 and HF without COVID-19 were affirmed (P>0.05). HF coupled with COVID-19 infection demonstrated an increased risk of 30-day mortality (28.91 vs. 14.63%; P=0.017), extended length of hospital stays (22.54±6.73 vs. 19.35±5.69; P<0.001) and higher expenses for hospitalization (P<0.001). Complications related to hospitalization, including pneumonia (76.56 vs. 35.37%; P=1.0x10-4), respiratory failure (47.66 vs. 24.39%; P=0.001), pulmonary embolism (8.59 vs. 2.44%; P=0.031), deep vein thrombosis (30.47 vs. 14.63%; P=0.009), 7 days delirium (60.16 vs. 45.12%; P=0.033), multiple organ dysfunction syndrome (32.81 vs. 18.29%; P=0.021) and neurological deficits (30.47% vs. 17.07%, P=0.029) increased significantly. In conclusion, HF combined with COVID-19, treatment and prognosis are getting worse. Enhancing preparedness for future COVID-19 and other similar pandemics necessitates the comprehension of this to refine care provided to patients with HF (registration no. THH-IPR-20221101 on 01 November 2022).
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