Related Experiment Video

Updated: Jun 29, 2025

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

9.8K

Mechanisms of angiogenesis in tumour

Run Zhang1, Yutong Yao1, Hanwei Gao1

  • 1China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.

Frontiers in Oncology
|April 9, 2024
PubMed

Insights

Tumors use multiple angiogenesis pathways beyond vascular sprouting to resist antiangiogenic drugs. Understanding these diverse mechanisms is key to improving cancer treatment efficacy.

Area of Science:

  • Oncology
  • Cancer Biology
  • Vascular Biology

Background:

  • Angiogenesis is crucial for tumor growth and metastasis.
  • Antiangiogenic therapies targeting the VEGF pathway are standard oncology treatments.
  • Tumors can develop resistance to antiangiogenic drugs through various mechanisms.

Purpose of the Study:

  • To summarize recent research on six distinct tumor angiogenesis processes.
  • To explore mechanisms tumors use to evade antiangiogenic therapy.
  • To propose strategies for enhancing antiangiogenic treatment effectiveness.

Main Methods:

  • Review of current scientific literature on tumor angiogenesis.
  • Analysis of non-sprouting angiogenic mechanisms.
  • Examination of the link between angiogenesis and drug resistance.

Main Results:

  • Tumors employ six main angiogenesis mechanisms: sprouting angiogenesis, vasculogenic mimicry, vessel intussusception, vascular co-option, cancer stem cell-derived angiogenesis, and bone marrow-derived angiogenesis.
  • Non-sprouting angiogenesis pathways are often independent of the VEGF signaling pathway.
  • Tumor angiogenesis reprogramming contributes to enhanced drug resistance and treatment failure.

Conclusions:

  • Targeting only VEGF-driven sprouting angiogenesis is insufficient for effective cancer treatment.
  • Developing strategies that address multiple angiogenesis mechanisms is essential.
  • Further research into alternative angiogenic pathways can lead to more effective antiangiogenic therapies.
Keywords:
anti-angiogenesis therapysprouting angiogenesistumour microenvironmentvascular co-optionvasculogenic mimicry

More Related Videos

Isolation and Culture Expansion of Tumor-specific Endothelial Cells10:15

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

11.2K
Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

922

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K