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Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study

Xiang-Zhi Hu1, Ling-Ling Fu2, Bin Ye2

  • 1Medical College, Guizhou University, Guiyang, China.

Frontiers in Cardiovascular Medicine
|April 9, 2024
PubMed

Insights

This study used Mendelian randomization to investigate the causal link between gut microbiota and coronary heart disease (CHD). Certain gut bacteria were found to be causally associated with CHD risk.

Area of Science:

  • Microbiome research
  • Cardiovascular epidemiology
  • Genetic epidemiology

Background:

  • Observational studies suggest a link between gut microbiota and coronary heart disease (CHD).
  • The causal relationship between gut microbiota and CHD remains largely unexplored.

Purpose of the Study:

  • To investigate the causal effect of gut microbiota on coronary heart disease (CHD).
  • To utilize Mendelian randomization (MR) analysis for exploring this association.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) approach.
  • Utilized single-nucleotide polymorphisms (SNPs) associated with gut microbiota as instrumental variables.
  • Applied the inverse variance-weighted (IVW) method for analysis.

Main Results:

  • Identified suggestive causal associations between specific gut bacteria and CHD.
  • Notable taxa included Class Actinobacteria, Class Lentisphaeria, Family Clostridiales vadinBB60group, Genus *Clostridium innocuum* group, Genus *Bifidobacterium*, Genus *Butyricicoccus*, Genus *Oxalobacter*, Genus *Turicibacter*, and Order Victivallales.

Conclusions:

  • This Mendelian randomization study provides evidence for a causal association between gut microbiota and coronary heart disease (CHD).
  • Further research, including randomized controlled trials, is warranted to explore the potential protective effects of probiotics in CHD and their mechanisms.
Abstract

Keywords:
Mendelian randomization studycausal inferencecoronary heart diseasegut microbiotainverse variance-weighted

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