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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Cisplatin-Based Combination Therapy for Enhanced Cancer Treatment.

Qi Li1, Siwei Chen1, Xiao Wang1

  • 1Institute of Pharmacy & Pharmacology, University of South China, Hengyang, Hunan, China.

Current Drug Targets
|April 9, 2024
PubMed
Summary

Cisplatin combination therapy shows promise for overcoming cancer drug resistance and reducing toxicity. This review explores strategies and applications to guide optimal treatment regimens.

Keywords:
Cisplatinchemotherapeutic drugco-administration strategycombination therapyhepatotoxicity.improved cancer treatmentnephrotoxicity

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

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Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Cisplatin is a vital chemotherapy drug for tumor treatment.
  • Clinical efficacy is limited by drug resistance, relapse, poor prognosis, and normal tissue toxicity.
  • Cisplatin-based combination therapy is increasingly studied to enhance efficacy and reduce side effects.

Purpose of the Study:

  • To review co-administration strategies for cisplatin-based drug combinations.
  • To discuss therapeutic effects, mechanisms, and clinical applications of seven cisplatin combination therapies.
  • To provide guidance for developing optimal cisplatin combination regimens.

Main Methods:

  • Review of preclinical and clinical research on cisplatin combination therapies.
  • Analysis of three primary co-administration strategies.
  • Examination of seven specific combination therapy types.

Main Results:

  • Cisplatin combination therapy can overcome resistance and reduce toxicity.
  • Different combination strategies offer distinct advantages and disadvantages.
  • Preclinical data and clinical applications vary across the seven discussed therapies.

Conclusions:

  • Cisplatin combination therapy holds significant potential for improved cancer treatment.
  • Further research is needed to optimize combination regimens.
  • Addressing future prospects and challenges is crucial for clinical translation.