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Published on: February 23, 2014
Pneumococci Isolated From Children in Community-Based Practice Differ From Isolates Identified by Population- and
Ravinder Kaur1, Ryan Gierke2, Lesley McGee2
1Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.
Insights
Pneumococcal strains causing ear infections in children differ from invasive disease strains. Non-vaccine serotype 35B is increasingly linked to both conditions, highlighting a need for updated vaccine strategies.
Area of Science:
- * Microbiology and Infectious Diseases
- * Vaccinology and Public Health
Background:
- * Understanding pneumococcal serotype distribution is crucial for evaluating the effectiveness of pneumococcal conjugate vaccines (PCVs).
- * Characterizing strains causing both noninvasive and invasive pneumococcal disease (IPD) can inform vaccine development and public health strategies.
Purpose of the Study:
- * To compare pneumococcal serotype distribution and antibiotic nonsusceptibility between acute otitis media (AOM) cases and invasive pneumococcal disease (IPD) cases in children.
- * To identify emerging serotypes and their association with antibiotic resistance.
Main Methods:
- * Analysis of nasopharyngeal and middle ear fluid (MEF) pneumococcal isolates from children with AOM in Rochester, NY (2011-2019).
- * Comparison with IPD isolates from the US-based Active Bacterial Core surveillance (ABCs) system.
- * Evaluation of serotype distribution and antibiotic resistance patterns.
Main Results:
- * Distinct serotype distributions were observed between AOM and IPD cases.
- * Non-vaccine serotypes 35B and 21 were more prevalent in Rochester AOM cases.
- * Serotype 35B emerged as a common cause of antibiotic-nonsusceptible AOM and IPD between 2015-2019.
Conclusions:
- * Pneumococcal isolates from pediatric AOM cases in Rochester exhibit different serotype and antibiotic susceptibility profiles compared to IPD cases.
- * The emergence of non-vaccine serotype 35B in both AOM and IPD underscores its significance as a public health concern.
Background:
Characterizing strains causing noninvasive and invasive pneumococcal disease (IPD) may inform the impact of new pneumococcal conjugate vaccines (PCVs).
Methods:
During 2011-2019, among children aged 6-36 months, pneumococcal serotype distribution and antibiotic nonsusceptibility of nasopharyngeal and middle ear fluid (MEF) isolates collected at onset of acute otitis media (AOM) in Rochester, New York, were compared with IPD isolates from the Active Bacterial Core surveillance (ABCs) system across 10 US sites.
Results:
From Rochester, 400 (nasopharyngeal) and 156 (MEF) pneumococcal isolates were collected from 259 children. From ABCs, 907 sterile-site isolates were collected from 896 children. Non-PCV serotypes 35B and 21 were more frequent among the Rochester AOM cases, while serotypes 3, 19A, 22F, 33F, 10A, and 12F contained in PCVs were more frequent among ABCs IPD cases. The proportion of antibiotic-nonsusceptible pneumococcal isolates was generally more common among IPD cases. In 2015-2019, serotype 35B emerged as the most common serotype associated with multiclass antibiotic nonsusceptibility for both the Rochester AOM and ABCs IPD cases.
Conclusions:
Pneumococcal isolates from children in Rochester with AOM differ in serotype distribution and antibiotic susceptibility compared to IPD cases identified through US surveillance. Non-PCV serotype 35B emerged as a common cause of AOM and IPD.
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