Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed type hypersensitivity in atopic dermatitis.

E Young, C Bruijnzeel-Koomen, L Berrens

    Acta Dermato-Venereologica. Supplementum
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Impact of Hiatus Hernia Size on Dysplasia Progression in Patients With Barrett's Esophagus.

    JGH open : an open access journal of gastroenterology and hepatology·2026
    Same author

    Corrigendum to "Plutonium and other radionuclides persist across marine-to-terrestrial ecotopes in the Montebello Islands sixty years after nuclear tests" [Sci. Total Environ. Volume 691, 15 November 2019, pages 572-583].

    The Science of the total environment·2024
    Same author

    Commentary: Effect of cochlear implantation on vestibular function in children: A scoping review.

    Frontiers in pediatrics·2023
    Same author

    Results of a single-arm pilot study of <sup>32</sup>P microparticles in unresectable locally advanced pancreatic adenocarcinoma with gemcitabine/nab-paclitaxel or FOLFIRINOX chemotherapy.

    ESMO open·2021
    Same author

    Gastrointestinal: A case of cold-snare polypectomy perforation: Avoiding this rare complication.

    Journal of gastroenterology and hepatology·2021
    Same author

    Improved Constraints on Primordial Gravitational Waves using Planck, WMAP, and BICEP/Keck Observations through the 2018 Observing Season.

    Physical review letters·2021

    Patients with atopic dermatitis (A.D.) exhibit altered hypersensitivity responses. Studies show reduced reactions to bacterial vaccines and unique responses to human dander allergens, suggesting A.D. influences immune reactions.

    Area of Science:

    • Immunology
    • Dermatology
    • Allergy

    Background:

    • Atopic dermatitis (A.D.) is a complex inflammatory skin condition.
    • Delayed type hypersensitivity plays a role in various dermatological conditions.
    • Understanding immune responses in A.D. is crucial for effective management.

    Purpose of the Study:

    • To investigate delayed type hypersensitivity in atopic dermatitis.
    • To compare hypersensitivity reactions in A.D. patients with other dermatological groups.
    • To assess responses to bacterial vaccines, various allergens, and house dust mite allergens.

    Main Methods:

    • Intradermal testing with bacterial vaccines.
    • Patch testing with various substances in A.D. patients and controls.
    • Patch testing with human dander fractions and house dust mite allergen P1 after stratum corneum stripping.

    Related Experiment Videos

  • Histopathological examination of skin reactions.

    • Main Results:

    • Patients with A.D. showed significantly lower positive reactions to bacterial vaccines compared to controls.
    • Distinct differences in patch test reactions were observed between A.D. patients and those with anal eczema.
    • A.D. patients exhibited positive patch test reactions to human dander fractions and house dust mite allergen P1, with reactions peaking at 24-48 hours.
    • Histopathology confirmed eczema-type reactions.

    Conclusions:

    • Atopic dermatitis patients display altered delayed type hypersensitivity patterns.
    • While human dander allergens may not have a specific role in A.D. pathogenesis, they can elicit both immediate and delayed skin reactions.
    • These findings highlight the unique immunological profile of individuals with atopic dermatitis.