The Role of Pan-Immune-Inflammation Value in Determining the Severity of Coronary Artery Disease in NSTEMI Patients

Area of Science:

• Cardiology
• Inflammation Markers
• Biomarkers

Background:

• Non-ST elevation myocardial infarction (NSTEMI) patients face residual cardiovascular risk despite advancements.
• Early identification of high-risk NSTEMI patients is crucial for improved outcomes.
• Novel indicators are needed to stratify risk in NSTEMI patients.

Purpose of the Study:

• To investigate the association between the pan-immune-inflammation value (PIV) and coronary artery disease (CAD) severity.
• To determine if PIV can predict high SYNTAX scores (SxS) in NSTEMI patients.

Main Methods:

• Coronary artery disease (CAD) patients were categorized into three groups based on SYNTAX score (SxS).
• Multivariate logistic regression analysis was used to identify risk variables.
• Receiver-operating characteristic (ROC) curve analysis evaluated PIV's predictive performance.

Main Results:

• PIV independently predicted high SxS in NSTEMI patients (OR: 1.003, P=0.005).
• A significant positive correlation was observed between PIV and SxS (r=0.68, P<0.001).
• PIV demonstrated high sensitivity (91%) and specificity (81.1%) in predicting severe coronary lesions at a cutoff of 568.2.

Conclusions:

• The pan-immune-inflammation value (PIV) is a cost-effective and readily available laboratory marker.
• PIV is substantially correlated with high SYNTAX scores and CAD severity in NSTEMI patients.
• PIV can aid in identifying NSTEMI patients with severe coronary artery disease.