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Direct Mouse Trauma/Burn Model of Heterotopic Ossification

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Lower Extremity Trauma: A Multidimensional Reconstructive Approach with Hyperbaric Oxygen Therapy.

Caterina Marra¹, Paola Pentangelo¹, Luigi Losco¹

¹Plastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, SA, Italy.

Journal of Clinical Medicine

|April 9, 2024

Summary

Hyperbaric oxygen therapy (HBOT) combined with reconstructive surgery improves healing outcomes for distal lower extremity trauma. HBOT reduces complications and speeds recovery for complex soft tissue defects.

Keywords:

ADM HBOT NPWT acellular dermal matrix hyperbaric oxygen therapy lower extremity reconstruction lower limb trauma negative pressure wound therapy soft tissue defect split thickness skin graft

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Area of Science:

Orthopedic Surgery
Wound Healing
Hyperbaric Medicine

Background:

Distal lower extremity trauma presents significant reconstructive challenges.
Developing effective treatment protocols for soft tissue defects is crucial.
Integrating hyperbaric oxygen therapy (HBOT) offers potential advantages.

Purpose of the Study:

To propose and evaluate a protocol for treating traumatic distal lower extremity soft tissue defects.
To assess the efficacy of combining reconstructive surgery with HBOT.
To analyze outcomes and complication rates in patients undergoing these procedures.

Main Methods:

Retrospective analysis of 57 patients with lower extremity trauma (2010-2021).
Inclusion of microbiological sampling, debridement, and reconstructive surgery.
Comparison between a control group and a group receiving HBOT prior to reconstruction.
Application of Negative Pressure Wound Therapy (NPWT) as needed.

Main Results:

All patients achieved complete recovery with minimal complications.
The HBOT group exhibited lower complication rates and graft loss.
No HBOT-related complications were reported.
Significant reductions in time to complete healing (p=0.002) and reconstruction-to-healing interval (p<0.00001) were observed with HBOT.

Conclusions:

Pre-operative HBOT in conjunction with reconstructive surgery reduces complications and accelerates healing in distal lower extremity soft tissue defects.
HBOT administration prior to reconstruction significantly shortens healing times.
Further prospective studies and randomized trials are warranted to confirm HBOT efficacy in larger patient cohorts.