Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

160
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
160
Pharmacovigilance01:19

Pharmacovigilance

830
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
830
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

414
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
414

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease.

Internal medicine journal·2026
Same author

Efficacy and Tolerability of Weekly Bortezomib, Lenalidomide, and Dexamethasone Protocols in Transplant-Ineligible Newly Diagnosed Myeloma: An Australian Real-World, Multicenter Study.

Asia-Pacific journal of clinical oncology·2026
Same author

Early de-escalation of broad-spectrum antibiotic therapy in febrile neutropenia.

Internal medicine journal·2026
Same author

Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes.

Nature communications·2025
Same author

Practice Patterns in Management of Low- to Intermediate-Grade Salivary Gland Carcinoma: A Multi-Institutional Study.

Laryngoscope investigative otolaryngology·2025
Same author

Risk factors and survival impact of severe radiation-related late toxicities in head and neck cancer-a cohort study.

Lancet regional health. Americas·2025

Related Experiment Video

Updated: Jun 29, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.2K

Characterising vincristine-induced peripheral neuropathy in adults: symptom development and long-term persistent

Tiffany Li1,2, Terry Trinh3, Annmarie Bosco3,4

  • 1Brain and Mind Centre, The University of Sydney, Sydney, Australia.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|April 9, 2024
PubMed
Summary
This summary is machine-generated.

Vincristine-induced peripheral neuropathy (VIPN) affects most adult patients, causing sensorimotor issues and disability. While some recovery occurs, long-term symptoms can persist, impacting quality of life.

Keywords:
Natural historyNerve conductionPatient reported outcomesPhenotypeVincristine-induced peripheral neuropathy

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

9.5K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

23.7K

Related Experiment Videos

Last Updated: Jun 29, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.2K
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

9.5K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

23.7K

Area of Science:

  • Neurology
  • Oncology
  • Clinical Pharmacology

Background:

  • Vincristine is a key chemotherapy for hematological malignancies.
  • Vincristine-induced peripheral neuropathy (VIPN) is a common, debilitating, and untreatable side effect.
  • A comprehensive understanding of VIPN characteristics in adults is lacking.

Purpose of the Study:

  • To conduct a detailed phenotyping of vincristine-induced peripheral neuropathy in adult patients.
  • To characterize the sensorimotor symptoms, functional impact, and recovery patterns of VIPN.

Main Methods:

  • Cross-sectional and prospective assessment of 57 adult patients post-vincristine treatment.
  • Utilized patient-reported outcomes (EORTC-QLQ-CIPN20, R-ODS) and neurological assessments (Total Neuropathy Score, nerve conduction studies).
  • Included sensory threshold and fine motor tasks; statistical comparisons performed using t-tests and Mann-Whitney U tests.

Main Results:

  • VIPN developed in 77.8% of patients by mid-treatment and persisted in 75% by end-of-treatment.
  • At 3 months post-treatment, 50% of patients still reported VIPN, with significant improvements in neurological grading and function.
  • VIPN manifested as sensorimotor deficits in upper and lower limbs, linked to reduced nerve amplitudes, impaired fine motor skills, and increased disability.

Conclusions:

  • VIPN in adults is a sensorimotor neuropathy affecting both upper and lower limbs, significantly impairing function and increasing disability.
  • While some patients experience neuropathy recovery, VIPN symptoms can be persistent, affecting long-term quality of life.