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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Two Cases Of Gastric Cancer With Elevated Serum Levels Of Kl-6

Two cases of gastric cancer with elevated serum levels of KL-6

Naoe Yanagisawa1, Naohiko Koide2, Harunari Fukai2

  • 1Department of Surgery, Nagano Prefectural Kiso Hospital, 6613-4 Fukushima, Kiso, Nagano, 397-8555, Japan. naoe4800@yahoo.co.jp.

Surgical Case Reports
|April 9, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Serum Krebs von den Lungen-6 (sKL-6) may indicate interstitial pneumonia and elevated in cancer. Two gastric cancer cases treated with SOX chemotherapy showed decreased sKL-6, suggesting its role as a tumor marker in advanced gastric cancer.

Area of Science:

  • Oncology
  • Pulmonology
  • Biochemistry

Background:

  • Serum Krebs von den Lungen-6 (sKL-6) is a known biomarker for interstitial pneumonia.
  • Elevated sKL-6 levels are also observed in cancer patients.
  • Limited data exists on sKL-6 in gastric cancer (GC) patients undergoing chemotherapy.

Purpose of the Study:

  • To report two cases of advanced gastric cancer with elevated sKL-6 treated with oxaliplatin plus S-1 (SOX) chemotherapy.
  • To analyze the changes in sKL-6 levels during and after chemotherapy.
  • To explore the potential role of sKL-6 as a tumor marker in gastric cancer.

Main Methods:

  • Case presentation of two patients diagnosed with gastric cancer and elevated sKL-6.
  • Treatment with oxaliplatin plus S-1 (SOX) chemotherapy, with one patient also receiving trastuzumab.
Keywords:
Gastric cancerKL-6OxaliplatinS-1

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  • Monitoring of sKL-6 serum levels and tumor response via imaging (CT, EGD) throughout treatment.

    • Main Results:

    • Both patients presented with advanced gastric cancer and significantly elevated sKL-6 levels.
    • Following SOX chemotherapy, both patients showed a marked decrease in sKL-6 levels.
    • Tumor burden (liver metastases, nodal metastases) also reduced significantly in both cases.
    • One patient developed interstitial pneumonia during prolonged chemotherapy, correlating with a slight sKL-6 increase.

    Conclusions:

    • Elevated sKL-6 in gastric cancer patients may serve as a tumor marker, particularly in cases with multiple metastases.
    • sKL-6 monitoring can be valuable for assessing treatment response in advanced gastric cancer.
    • sKL-6's dual role as an indicator for interstitial pneumonia and a tumor marker in GC warrants further investigation.
    Tumor marker