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  1. Home
  3. Cachexia Index For Prognostication In Surgical Patients With Locally Advanced Oesophageal Or Gastric Cancer: Multicentre Cohort Study.
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  3. Cachexia Index For Prognostication In Surgical Patients With Locally Advanced Oesophageal Or Gastric Cancer: Multicentre Cohort Study.

Related Experiment Video

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Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer:

Leo R Brown1,2, Georgina G Thomson1, Ellen Gardner2

  • 1Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.

The British Journal of Surgery
|April 9, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The novel cachexia index (CXI) effectively predicts disease progression and survival in oesophagogastric cancer patients undergoing neoadjuvant chemotherapy. Low CXI indicates a poorer prognosis, aiding clinical decision-making.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Biomarker Research

Background:

  • Cancer cachexia significantly impacts patient outcomes but is underutilized in clinical decision-making.
  • The cachexia index (CXI) is a novel prognostic marker for cancer cachexia.
  • This study evaluated the CXI's value in patients with oesophagogastric cancer receiving neoadjuvant chemotherapy and surgery.

Purpose of the Study:

  • To assess the prognostic value of the cachexia index (CXI) in patients with locally advanced oesophagogastric cancer.
  • To determine if CXI can predict disease progression during neoadjuvant chemotherapy.
  • To evaluate the association of CXI with postoperative mortality and overall survival.

Main Methods:

  • A cohort of 385 patients with locally advanced oesophagogastric cancer was identified.
  • The cachexia index (CXI) was calculated using L3 skeletal muscle index, serum albumin, and neutrophil-lymphocyte ratio.
  • Sex-stratified cut-off values for CXI were established, and patients were grouped into low or normal CXI categories.

    • Main Results:

    • Patients with a low CXI exhibited higher rates of disease progression during neoadjuvant chemotherapy (28% vs. 12%).
    • Low CXI was significantly associated with increased postoperative mortality (P = 0.019).
    • A low CXI correlated with substantially decreased overall survival (14.9 months vs. 56.9 months).

    Conclusions:

    • The cachexia index (CXI) is a valuable prognostic tool for locally advanced oesophagogastric cancer.
    • CXI can improve prognostication and guide clinical decision-making for these patients.
    • Integrating CXI assessment may enhance patient management and outcomes.