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Risk relationship between inflammatory bowel disease and urolithiasis: A two-sample Mendelian randomization study.
Wenqiang Fu1, Bin Zhu2, Jun Chen3
1Affiliated Hospital, Anorectal, Panzhihua University, Panzhihua, Sichuan, China.
This study found a genetic link between inflammatory bowel disease (IBD) and urolithiasis, suggesting IBD increases the risk of kidney stones. Early detection and prevention strategies are crucial for patients with IBD.
Area of Science:
- Genetics
- Gastroenterology
- Urology
Background:
- The genetic link between inflammatory bowel disease (IBD) and urolithiasis is not well understood due to challenges in determining disease onset.
- This study aims to clarify the causal genetic relationship between IBD and urolithiasis.
Purpose of the Study:
- To investigate the causal genetic association between inflammatory bowel disease (IBD) and urolithiasis using Mendelian randomization (MR).
Main Methods:
- A two-sample MR analysis was conducted using large genome-wide association study (GWAS) datasets for IBD (n=59,957) and its subtypes, Crohn's disease (CD) and ulcerative colitis (UC), along with urolithiasis (n=218,792).
- Inverse-variance weighting, MR-Egger, and weighted medians were employed to analyze the summarized GWAS data.
Main Results:
- A significant unidirectional positive causal correlation was found between IBD and urolithiasis (OR, 1.04; P=0.01).
- Crohn's disease showed a strong association with urolithiasis (OR, 1.04; P=0.01), while ulcerative colitis showed a non-significant association (OR, 0.99; P=0.71).
- No significant pleiotropic effects were detected between IBD and urolithiasis.
Conclusions:
- A positive causal relationship exists between IBD and urolithiasis, with varying associations across IBD subtypes.
- Clinical awareness of increased urolithiasis risk in IBD patients is essential for early detection, prevention, and improved patient outcomes.
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