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Updated: Jun 28, 2025

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NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas

Lee-Moay Lim1,2,3, Yi-Chen Lee4,5, Ting-Wei Lin1

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

The Kaohsiung Journal of Medical Sciences
|April 9, 2024
PubMed
Summary

Neurotrophic receptor tyrosine kinase 3 (NTRK3) promotes aggressive behaviors in upper tract urothelial carcinoma (UTUC). Higher NTRK3 expression correlates with worse patient survival and facilitates cancer cell migration and invasion via the AKT-mTOR pathway.

Keywords:
AKT‐mTOR pathwayneurotrophic receptor tyrosine kinase 3 (NTRK3)prognosistropomyosin‐related kinase (TrK)upper tract urothelial carcinoma (UTUC)

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