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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
227
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

449
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
449
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

173
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
173
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
145
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

161
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
161
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Recurrent Crohn's disease.

Mahmoud Shehada1, Lisa E McMahon2

  • 1Department of Surgery, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA.

Seminars in Pediatric Surgery
|April 9, 2024
PubMed
Summary

Surgical recurrence after ileocolic Crohn's disease surgery is common. This review examines factors influencing recurrence, surgical indications, and techniques, drawing from limited pediatric and adult data.

Keywords:
AnastomosisCrohn's diseaseIleocolicPediatricsRecurrence

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Area of Science:

  • Pediatric Gastroenterology
  • Surgical Gastroenterology
  • Inflammatory Bowel Disease Research

Background:

  • Surgical management of pediatric Crohn's disease aims for growth and development, not a cure.
  • Anastomotic recurrence is a significant complication following ileocolic surgery.
  • Limited data exists on factors contributing to surgical recurrence in pediatric Crohn's disease.

Purpose of the Study:

  • To review the epidemiology of recurrent ileocolic Crohn's disease post-surgery.
  • To outline indications for surgical intervention in pediatric cases.
  • To summarize surgical techniques reported in the literature.

Main Methods:

  • Literature review focusing on pediatric Crohn's disease.
  • Extrapolation of findings from adult Crohn's disease literature due to scarcity of pediatric data.
  • Analysis of epidemiological factors, surgical indications, and techniques.

Main Results:

  • Recurrent ileocolic Crohn's disease at the anastomosis is a frequent issue.
  • Factors influencing recurrence are not well-defined in pediatric populations.
  • Much of the current understanding is derived from adult studies.

Conclusions:

  • While not curative, ileocolic surgery is vital for pediatric Crohn's disease management.
  • Further research is needed to clarify recurrence factors and optimize surgical strategies in children.
  • Current surgical approaches rely heavily on adult data, highlighting a gap in pediatric-specific evidence.