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Tumour-regulatory role of long non-coding RNA HOXA-AS3
Zhi Xiong Chong1, Wan Yong Ho1, Swee Keong Yeap2
1Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor, Malaysia.
Progress in Biophysics and Molecular Biology
|April 9, 2024
Summary
Dysregulated long non-coding RNA HOXA-AS3 promotes cancer by acting as a competing RNA (ceRNA), impacting miRNA activity and key pathways. Further research is needed to confirm its potential as a diagnostic biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA (lncRNA) HOXA-AS3 dysregulation is implicated in various cancer types.
- HOXA-AS3 exhibits tumor-modulatory roles and prognostic significance across different cancers.
- Its overexpression is frequently observed in human cancers.
Purpose of the Study:
- To review the tumor-regulatory roles and potential applications of lncRNA HOXA-AS3 in cancer.
- To elucidate the molecular mechanisms underlying HOXA-AS3's oncogenic functions.
- To highlight HOXA-AS3 as a potential biomarker and therapeutic target.
Main Methods:
- Literature review of observational, in vitro, and in vivo studies on HOXA-AS3.
- Analysis of HOXA-AS3's function as a competing endogenous RNA (ceRNA).
- Investigation of HOXA-AS3's interactions with microRNAs (miRNAs) and protein targets.
Main Results:
- HOXA-AS3 acts as a ceRNA, inhibiting multiple miRNAs (e.g., miR-29 family, miR-218-5p) and upregulating downstream oncogenic mRNAs.
- It regulates key cancer-associated pathways, including WNT/β-catenin and epithelial-to-mesenchymal transition (EMT).
- HOXA-AS3 interacts with proteins like HOXA3 and HOXA6, influencing oncogenic signaling.
Conclusions:
- HOXA-AS3 is a promising biomarker for cancer diagnosis and prognosis due to its overexpression.
- Targeting HOXA-AS3 represents a potential therapeutic strategy to inhibit cancer progression.
- Further mechanistic studies and large-scale clinical trials are essential to validate its roles and develop inhibitors.
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