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The association between leptin and diabetes: A meta-analysis
Xin-Yu Wu1, Han-Bing Song2, Jian-Wei Wang1
1Department of Traditional Chinese Medicine, School of Basic Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
The Journal of Obstetrics and Gynaecology Research
|April 9, 2024
Summary
Leptin levels are significantly elevated in patients with diabetes, particularly gestational diabetes mellitus. However, serum leptin levels do not differ between type 2 diabetes and control groups.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Clinical Research
Background:
- Leptin, a hormone produced by adipocytes, plays a crucial role in regulating energy balance and metabolism.
- Altered leptin levels have been implicated in the pathophysiology of various metabolic disorders, including diabetes mellitus.
- Understanding the relationship between leptin and diabetes is essential for developing targeted therapeutic strategies.
Purpose of the Study:
- To determine the relationship between leptin and diabetes through a comprehensive meta-analysis.
- To investigate whether leptin levels differ in patients with different types of diabetes compared to non-diabetic individuals.
Main Methods:
- A systematic literature search was conducted across PubMed, EMBASE, Cochrane Library, and CNKI databases.
- Meta-analysis was performed using Standardized Mean Difference (SMD) with 95% confidence intervals (CIs).
- Heterogeneity was assessed using the Chi-square-based Q test and I² statistics, with sensitivity and publication bias analyses performed.
Main Results:
- The meta-analysis included 10 studies with 1879 participants (1024 diabetic, 855 non-diabetic).
- Serum leptin levels were significantly higher in diabetic patients (SMD = 1.78, 95% CI [0.81, 2.76]).
- Elevated leptin levels were particularly pronounced in gestational diabetes mellitus (SMD = 3.03, 95% CI [1.21, 4.86]), but no significant difference was found in type 2 diabetes (SMD = 0.34, 95% CI [-1.06, 1.74]).
Conclusions:
- Serum leptin levels are significantly elevated in individuals with diabetes mellitus.
- The elevation in leptin is most pronounced in gestational diabetes mellitus.
- No significant difference in serum leptin levels was observed between type 2 diabetes and control groups in this meta-analysis.
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