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Trajectory patterns and cumulative burden of CEA during follow-up with non-small cell lung cancer outcomes: A retrospective longitudinal cohort study

  • 0Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
British Journal of Cancer +

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April 9, 2024

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April 9, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Serial carcinoembryonic antigen (CEA) levels, not single measurements, predict non-small cell lung cancer (NSCLC) survival. Tracking CEA trajectories and cumulative burden offers crucial prognostic insights for NSCLC patients post-surgery.

Area Of Science

  • Oncology
  • Biomarker Research
  • Cancer Prognostics

Background

  • Prior non-small cell lung cancer (NSCLC) research primarily analyzed single Carcinoembryonic Antigen (CEA) measurements.
  • This approach overlooked the prognostic value of serial CEA level changes over time.

Purpose Of The Study

  • To investigate the prognostic significance of longitudinal Carcinoembryonic Antigen (CEA) patterns in surgically treated non-small cell lung cancer (NSCLC).
  • To evaluate the impact of cumulative CEA burden on patient survival and metastasis risk.

Main Methods

  • Retrospective cohort study of 2959 patients with stage I-III NSCLC who underwent surgery.
  • Latent class growth mixture modeling applied to analyze CEA trajectory patterns and cumulative burden.

Main Results

  • Four distinct CEA trajectory groups identified: low-stable, decreasing, early-rising, and later-rising.
  • Rising CEA trajectories and higher cumulative CEA burden were significantly associated with increased mortality risk.
  • Patients with rising CEA trajectories and high cumulative burden showed a higher likelihood of bone metastasis.
  • Five-year overall survival rates varied significantly across cumulative CEA burden quantiles and decreasing trajectory subgroups.

Conclusions

  • Longitudinal CEA trajectory patterns and cumulative CEA burden are independent prognostic factors in NSCLC.
  • Serial CEA monitoring is recommended for postoperative surveillance in NSCLC patients.

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