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Updated: Jun 28, 2025

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

Accelerating Diverse Cell-Based Therapies Through Scalable Design.

Emma L Peterman¹, Deon S Ploessl¹, Kate E Galloway¹

¹Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

Annual Review of Chemical and Biomolecular Engineering

|April 10, 2024

Summary

This summary is machine-generated.

Engineering cells with new genetic functions enhances cell-based therapies for immune surveillance and tissue regeneration. Advances in synthetic biology and genome writing accelerate the development of these innovative therapeutic tools.

Keywords:

biomanufacturing cell-based therapies cellular engineering genome editing stem cells synthetic biology

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Last Updated: Jun 28, 2025

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Area of Science:

Cellular engineering
Synthetic biology
Regenerative medicine

Background:

Cell-based therapies hold promise for immune surveillance and tissue regeneration.
Scaling up cell engineering with transgenic components presents a significant challenge.
Current methods require advancement for precision editing of therapeutic cells.

Purpose of the Study:

To review applications for engineering primary and stem cells in cell-based therapies.
To highlight tools and advances in mammalian cell engineering.
To examine tailoring transgenesis methods and genetic cargo for optimal performance.

Main Methods:

Review of current literature on cell engineering and synthetic biology tools.
Analysis of transgenesis methods and genetic cargo design strategies.
Exploration of advanced genome writing techniques for cellular tool development.

Main Results:

Mammalian cell engineering has advanced from bioproduction to precision editing.
Diverse cell types can be engineered for therapeutic applications.
Synthetic biology tools and genome writing techniques are expanding cellular engineering capabilities.

Conclusions:

Harnessing diverse cell types and synthetic biology tools can accelerate cell-based therapy translation.
Advanced genome writing techniques are crucial for building sophisticated cellular tools.
Tailoring genetic engineering approaches is key to realizing the full potential of cell-based therapies.