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Role of non-coding RNAs mediated pyroptosis on cancer therapy: a review

Dan Zhao1,2, Tangwei Wu2, Zheqiong Tan2

  • 1School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China.

Expert Review of Anticancer Therapy
|April 10, 2024
PubMed
Abstract

Insights

Non-coding RNAs (ncRNAs) significantly impact cancer progression and therapy by regulating pyroptosis, a programmed cell death. These ncRNAs offer potential as biomarkers and novel anti-cancer strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs) regulate gene expression and are implicated in tumor progression.
  • Pyroptosis, an inflammatory programmed cell death, is increasingly recognized for its role in cancer.
  • Drug resistance necessitates novel therapeutic strategies, with pyroptosis emerging as a promising target.

Purpose of the Study:

  • To review the role of ncRNAs in pyroptosis-mediated cancer therapy.
  • To explore ncRNAs as potential biomarkers for cancer diagnosis and prognosis.
  • To provide insights into novel anti-cancer strategies targeting pyroptosis.

Main Methods:

  • Literature search conducted in December 2023.
  • Focus on studies investigating ncRNAs and pyroptotic cell death in cancer therapy.
  • Synthesis of findings on mechanisms and clinical applications.

Main Results:

  • ncRNAs influence cancer therapy outcomes (chemotherapy, radiotherapy, targeted therapy, immunotherapy) by regulating pyroptosis.
  • ncRNAs, including lncRNAs, miRNAs, and circRNAs, can act as biomarkers.
  • Mechanisms involve ceRNA networks and direct protein interactions modulating pyroptosis.

Conclusions:

  • ncRNAs play a critical role in pyroptosis, impacting cancer progression and treatment response.
  • ncRNAs hold significant potential as diagnostic and prognostic biomarkers.
  • Targeting ncRNA-modulated pyroptosis presents a promising avenue for developing innovative anti-cancer therapies.
Keywords:
biomarkercancer therapycircular RNAslong non-coding RNAsmicroRNAsnon-coding RNAspyroptosis

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