Intraparotid plexiform neurofibroma: A rare diagnostic challenge

Area of Science:

• Oncology
• Neurology
• Pathology

Background:

• Intraparotid neurofibromas are rare, often linked to neurofibromatosis type 1 (NF1).
• Diagnosis is difficult due to resemblance to salivary gland tumors.

Observation:

• An 18-year-old presented with a painful, growing parotid mass.
• Fine needle aspiration biopsy (FNAB) showed myxoid stroma and spindle cells.
• MRI revealed a plexiform neurofibroma involving the parotid gland and facial nerve.

Findings:

• Histopathology confirmed a plexiform neurofibroma.
• The absence of NF1 association makes this case unique.
• Cytological and radiological correlation is vital for diagnosis.

Implications:

• Accurate diagnosis and management of rare intraparotid neurofibromas are crucial.
• Surgical excision with facial nerve reconstruction may be required.
• Increased awareness of these rare tumors is essential for clinicians.