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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
Should soldiers take oral tranexamic acid before going into battle?
Nicolas Cazes1, Simon-Pierre Corcostegui, Steven Lovi
1From the Emergency Department (N.C.), Laveran Army Teaching Hospital, Marseille; Paris Fire Brigade (S.-P.C.); and French Military Health System (S.L., E.R., V.D., L.L., C.D.), Paris, France.
Abstract:
Tranexamic acid is an inexpensive antifibrinolytic treatment that reduces morbidity and mortality in civilian and military trauma patients. It must be administered within 3 hours of the injury, and its efficacy is greater the earlier it is given. It is already used preventively in the civilian environment in a number of indications to reduce bleeding and bleeding-related mortality. We wondered about the potential benefits of preventive oral administration of tranexamic acid prior to an assault for military personnel with a potential risk of injury.

