Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrathecal CRISPR-edited allogeneic IL-13Rα2 CAR T Cells for recurrent high-grade Glioma: preclinical characterization and phase I trial.

Nature communications·2026
Same author

Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading <i>GPRC5A</i>.

Frontiers in immunology·2025
Same author

Therapeutic Effect of a Recombinant Human Fibronectin Construct in Skeletal Muscle Repair and Oxidative Stress.

International journal of molecular sciences·2025
Same author

CAR Cell-Derived Exosomes in Cancer Therapy: Biogenesis, Engineering Strategies and Antitumor Mechanisms.

International journal of molecular sciences·2025
Same author

Effects of Nano-SiO<sub>2</sub> and Nano-CaCO<sub>3</sub> on Mechanical Properties and Microstructure of Cement-Based Soil Stabilizer.

Nanomaterials (Basel, Switzerland)·2025
Same author

Targeting m7G-enriched circKDM1A prevents colorectal cancer progression.

Molecular cancer·2024
Same journal

Explainable incremental-value analysis of apparent diffusion coefficient and arterial spin labeling radiomics for ATRX status prediction in glioblastoma.

Frontiers in oncology·2026
Same journal

Study-level factors associated with hematoma after ultrasound-guided vacuum-assisted breast lesion excision: a systematic review and meta-analysis using a T-P-B framework.

Frontiers in oncology·2026
Same journal

Feasibility and strategy analysis of radiotherapy consolidation following immunotherapy for stage IV esophageal squamous cell carcinoma.

Frontiers in oncology·2026
Same journal

Anastomosing hemangioma of the kidney: a case report.

Frontiers in oncology·2026
Same journal

Machine learning-based prediction of prolonged air leak after uniportal video-assisted thoracic surgery segmentectomy.

Frontiers in oncology·2026
Same journal

Past present and future of radiosensitization in cervical cancer.

Frontiers in oncology·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

689

Engineered exosomes in emerging cell-free therapy.

Chaohua Si1, Jianen Gao1, Xu Ma1

  • 1National Research Institute for Family Planning, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Frontiers in Oncology
|April 10, 2024
PubMed
Summary
This summary is machine-generated.

Engineered exosomes offer promising cell-free therapy potential for disease treatment. However, challenges in exosome engineering technology hinder their clinical application, requiring new development approaches.

Keywords:
cell-free therapydrug developmentengineered exosomesexosomemodification

More Related Videos

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.1K
Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.3K

Related Experiment Videos

Last Updated: Jun 28, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

689
Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.1K
Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles
05:36

Author Spotlight: Development of a Large-Scale, Reproducible Production Method for Exosome Mimetics Using Magnetic Nanoparticles

Published on: January 26, 2024

1.3K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Exosomes, a class of extracellular vesicles, are key players in intercellular communication.
  • Cell-free therapy using exosomes shows significant promise for various diseases.
  • Engineered exosomes offer enhanced therapeutic functions, driving interest in translational medicine.

Purpose of the Study:

  • To review the current research landscape of engineered exosomes.
  • To identify and discuss the challenges hindering exosome engineering technology.
  • To propose novel strategies for exosome modification and drug development.

Main Methods:

  • Literature review of recent advancements in exosome engineering.
  • Analysis of current technological limitations and challenges.
  • Synthesis of existing data to identify future research directions.

Main Results:

  • Significant progress has been made in engineering exosomes for therapeutic applications.
  • Key challenges remain in scalability, targeting, and production consistency.
  • Current engineering strategies often face limitations in clinical translation.

Conclusions:

  • Despite challenges, engineered exosomes hold immense potential for cell-free therapeutics.
  • Overcoming technological hurdles is crucial for advancing exosome-based therapies.
  • Future research should focus on innovative modification techniques and robust drug development.