Changes in distribution of some crucial elements in masseter myofibers following surgically induced trauma

Experimentally induced surgical trauma of the masseter muscle in rats led to changes in the distribution of some crucial intracellular elements as determined by microprobe analysis. Sulfur, phosphorus, and potassium values were lowered while sodium and chlorine levels were elevated. These changes were accompanied by increased formation of ice crystal artifacts in myofibers. The findings suggest that trauma causes alterations in cytoplasmic macromolecules and in the state of water in the cells. The method of analysis provides a means for the further evaluation of antiinflammatory drugs.