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Updated: Jul 22, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Ischemic stroke pathophysiology: A bibliometric and visualization analysis from 1990 to 2022.
Yiwen Bao1,2, Hu Qi1,2, Dejian Wang1,2
1State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, PR China.
This bibliometric analysis reveals research trends in ischemic stroke pathophysiology. China and the US lead, with key research areas including the central nervous system and molecular mechanisms.
Area of Science:
- Neurology
- Biomedical Research
- Public Health
Background:
- Ischemic stroke pathophysiology is crucial for scientific understanding and research interest is growing.
- A comprehensive bibliometric analysis of this field is currently lacking.
- This study addresses the need for a systematic overview of research in ischemic stroke pathophysiology.
Purpose of the Study:
- To conduct a bibliometric analysis of ischemic stroke pathophysiology research.
- To identify current research status and emerging hotspots.
- To predict future research trends in the field.
Main Methods:
- Searched the Web of Science Core Collection (1990-2022).
- Utilized CiteSpace, VOSviewer, and R package 'bibliometrix' for analysis.
- Analyzed countries, institutions, journals, authors, papers, and keywords.
Main Results:
- 7,578 records were analyzed, with China and the US as leading countries.
- Harvard University was the most active institution; 'Stroke' and Gregory YH Lip were most prolific.
- 'Nature Medicine' had the highest citations per article.
- Key research themes included central nervous system, mechanisms, biochemistry, and medical imaging.
- Peripheral organ damage and rehabilitation require further investigation.
Conclusions:
- This is the first bibliometric study mapping the knowledge structure of ischemic stroke pathophysiology over 32 years.
- Findings provide a reference for scholars exploring ischemic stroke pathophysiology.
- Highlights areas for future research focus, including peripheral organ damage and rehabilitation.
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