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Updated: Jun 28, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Progress and perspectives on cell-free regenerative endodontic therapy
Jian Zhou1,2,3, Yingying Su3,4, Song-Ling Wang1,3,5
1Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100069, China.
Abstract:
Although teeth with pulpitis/apical periodontitis are saved after successful endodontic therapy, they are devitalized and susceptible to reinfections and fractures. The development of biology-based approaches for dental pulp regeneration or repair is possible today because of recent advances in tissue engineering and biomaterials. Cell-free regenerative endodontic therapy offers a promising strategy for the treatment of necrotic immature permanent teeth in children and adolescents. However, studies are underway to determine whether this procedure can be applied to mature teeth.
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